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apalutamide will reduce the extent or influence of triazolam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs which have been CYP3A4 substrates may lead to decrease publicity to those drugs.darifenacin will raise the stage or outcom